Houston Methodist

Usage of Patient Specific Midbrain Organoids for In Vitro Modeling of Parkinson’s Disease

In the midbrain of patients with Parkinson’s disease (PD), the dopaminergic neurons of the substantia nigra region are vulnerable for degeneration, while those of the ventral tegmental area are not. This selective vulnerability is not understood, due to a lack of human-specific midbrain models. Schwamborn’s work shows that 3D differentiation of human midbrain neural progenitor cells leads to organoids that can produce and secrete dopamine, and contain other neuronal subtypes, astrocytes and oligodendrocytes. Enriching them with induced pluripotent stem cell derived microglia also generates patient and disease-specific midbrain organoids. Key hallmarks of PD can be recapitulated, while reproducibly generating 3D human midbrain organoids containing mDANs to investigate PD-relevant patho-mechanisms.

Jens Christian Schwamborn, PhD
Professor, Cellular and Developmental Biology
Luxembourg Centre for Systems Biomedicine (LCSB)
University of Luxembourg

Hosted by the Center for Neuroregeneration, Department of Neurosurgery

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Meeting ID: 963 4113 3137

Find your local number: https://zoom.us/u/aKxvYpFr6

Tuesday, October 20 at 10:00am to 11:30am

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Seminar, Webinar

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Department & Center
Neurological Institute, Department of Neurosurgery, Center for Neuroregeneration, Academic Institute

Jens Christian Schwamborn, PhD, Professor, Cellular and Developmental Biology, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg

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