Cell and Molecular events leading to Age-related Neurodegenerative Disease

Age is the greatest risk for age-related neurodegenerative disease. In Cell and Molecular Events Leading to Age-Related Neurodegenerative Disease, Fred H. (Rusty) Gage will discuss his team’s work using direct conversion of primarily sporadic Alzheimer's disease patient fibroblasts into induced neurons (iNs) to generate an age-equivalent neuronal model. Patient-derived iNs exhibit strong Alzheimer's disease-specific transcriptome neuronal signatures characterized by down-regulation of mature functional and morphological properties and up-regulation of immature neuronal and neural stem cell-associated pathways

Monthly lecture series hosted by the Center for Neuroregeneration.