Houston Methodist

Center for Neuroregeneration Lecture Series

Monthly lecture series hosted by the Center for Neuroregeneration.

“Tau Prions: Conformation-based Classification of Tauopathies”

“Neurodegenerative tauopathies are diverse disorders defined by brain accumulation of tau protein in fibrillar aggregates of unique structure. The Diamond lab first reported that tau functions as a prion, mediating the progression of neurodegenerative tauopathies based on trans-cellular propagation of pathology, a process termed “seeding.” The lab also reported the existence of self-propagating amyloid assemblies of defined conformation that are linked to different tauopathies. The Diamond lab has used simple cell models of tau prion activity, to define tauopathies based exclusively on prion seeding properties. The utility of conformation-based classification of tauopathies indicates that fundamental disease properties are linked intimately to tau assembly structures, with important implications for diagnosis and therapy.”

Marc Diamond, MD Director, Center for Alzheimer’s and Neurodegenerative Diseases Professor, Department of Neurology, UT Southwestern Medical Center

Thursday, February 2 at 12:00pm to 1:30pm

More dates through December 7, 2023

Houston Methodist Hospital, Walter Tower Columbia
6565 Fannin Street

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Department & Center
Center for Neuroregeneration

Marc Diamond, MD

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