Myasthenia gravis (MG) is characterized by fluctuating muscle weakness and fatigue of different muscle groups of the body, including ocular, bulbar, and skeletal muscles of the proximal limbs. Myasthenic crisis is a complication of MG characterized by worsening muscle weakness, resulting in respiratory failure that requires intubation and mechanical ventilation. This event presents the epidemiology, pathogenesis, and management of myasthenia gravis, focusing on the management of myasthenic crisis in the hospital setting.