Patients are dying every second! Directed by Wolfram, The Mayo Clinic Nanomedicine and Extracellular Vesicles Laboratory aims to develop the next generation of nanomedicines to bring cancer and regenerative treatments directly to the clinic. Extracellular vesicles (EVs)—naturally occurring nanoparticles secreted by all cells that are important in physiological and pathological processes—have promising applications as therapeutic agents, drug targets, delivery vehicles, and biomarkers. Though promising, the medical use of EVs is hindered by inefficient and non-scalable methods of isolation, such as ultracentrifugation (UC). The lab is overcoming these issues by optimizing a robust and scalable tangential flow filtration-based method for isolating EVs, thus opening up diagnostic and therapeutic opportunities. This talk highlights 1) lipoaspirate-derived EVs for treating tissue damage and inflammation, and 2) understanding the role and application of the EV glycome in metastatic disease.
Joy Wolfram, PhD
Assistant Professor of Medicine
Mayo Clinic - Jacksonville
Monday, April 15 at 11:00am to 12:00pm
Walter Tower, WT01-3018, Columbia 6551 Bertner Ave, WT01-3018