Houston Methodist

Nuclear Mechanobiology in Tumor Cell Migration

The Department of Nanomedicine presents:

Jan Lammerding, PhD
Associate Professor
Director of Graduate Studies
Nancy E. and Peter C. Meinig School of Biomedical Engineering
Weill Institute for Cell and Molecular Biology
Cornell University

Cancer metastasis is responsible for the vast majority of cancer deaths. During this process, tumor cells migrate through tight interstitial spaces. The deformability of the nucleus, the largest and stiffest organelle, forms a rate-limiting step during such confined 3D migration. At the same time, the physical stress associated with confined migration can result in nuclear envelope rupture, DNA damage, and epigenetic modifications, suggesting that tumor cell migration can increase the genomic instability of tumor cells and promote cancer progression. New insights into the underlying mechanisms may improve prognostic approaches and motivate novel therapies to control metastatic disease.

Thursday, May 30, 2019 at 3:00pm to 4:00pm

Houston Methodist Research Institute, Ernest H. Cockrell Boardroom R2-311
6670 Bertner Avenue

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Department of Nanomedicine
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