Francisco Altamirano, PhD
Internal Medicine & Cardiology
UT Southwestern Medical Center
Mutations in PKD1, the gene encoding polycystin-1 (PC1), underlie autosomal dominant polycystic kidney disease (ADPKD). ADPKD patients present with multiple cardiovascular co-morbidities believed to be caused by renal dysfunction. Altamirano focuses on understanding the role of PKD1 on cardiac function. PC1 within cardiomyocytes is essential to maintain both cardiac systolic and diastolic contractile function. PC1 ablation shortens the cardiomyocyte action potential, decreasing both Ca2+ transients and myocyte contractility. Altamirano’s work links the effects of PC1 ablation to an increase in outward potassium (Kv) currents in cardiomyocytes, resulting in accelerated repolarization and, consequently, impaired contractility. This evidence suggests that cardiomyocyte-autonomous effects of PKD1 may contribute to the cardiovascular abnormalities seen in ADPKD.
Monday, June 17 at 12:00pm to 1:00pm
Houston Methodist Hospital, Fondren 100 Conference Room
6565 Fannin Street