HES1-ATOH1 Alterations in Ulcerative Colitis Regulates Inflammation-Associated Intestinal Stem Cell Homeostasis and Transformation

OBJECTIVES

• Loss of HES1 expression as a novel biomarker in human sessile serrated adenoma/polyps (SSA/p), ulcerative colitis (UC) and IBD-associated colorectal cancers (CRC)
• Molecular features of KRAS mutant CRCs that show loss of HES1 expression
• Investigating how HES1-ATOH1 alteration regulates inflammation and tumorigenesis by regulating gut mucosal integrity, microflora, and immunity using a mouse model that resembles human HES1-negative UC and CRC