Just as recombinant protein therapies decades ago, RNA therapeutics are poised to transform healthcare. Therapeutic RNAs belong to different families including small interfering RNAs (siRNA) antisense oligonucleotides (ASOs), RNA aptamers, and coding RNAs, most often mRNA. mRNA therapies are indirect actors, with their encoded proteins providing the therapeutic effect. The Kiss lab has been creating new RNA therapy candidates since 2018. We currently have several different families of RNA therapy candidates (RNA vaccines, non-coding RNA, and coding RNAs) in proof of concept-stage and animal studies. I present some of my lab’s work to develop circular RNAs as a therapeutic platform.

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