Superhigh-Capacity Polymeric Micelles for Chemo/Immunotherapy of Cancer

The lecture focuses on the use of Poly(2-oxazoline) (POx)-based polymeric micelles (PMs), which have the unique ability to carry a high load of water-insoluble drugs. This capability enhances the solubility, stability, efficacy and safety of these drugs. The shape of the micelle influences the drug’s performance. The presentation also will discuss the relationship between drug loading, critical micelle concentration, the partitioning of micelles and serum proteins, pharmacokinetic and toxicokinetic profiles and efficacy. These innovative approaches hasten the application of novel PMs for therapeutic uses in cancer and other diseases. This research was funded by NIH grants CA198999 and CA264488. The conflict-of-interest statement indicates an affiliation with DelAQUA Pharmaceuticals.

Alexander (Sasha) Kabanov, PhD, DSc

Mescal Swain Ferguson Distinguished Professor, 
Center for Nanotechnology in Drug Delivery
Director, Center for Nanotechnology in Drug Delivery
UNC Eshelman School of Pharmacy
Co-Director, Carolina Institute for Nanomedicine
Adjunct Professor,  Biomedical Engineering
The University of North Carolina at Chapel Hill