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Glia Engineering for CNS wound repair

Regeneration after traumatic central nervous system (CNS) injury in adult mammals is limited because neural parenchymal cells lack sufficient self-renewal capacity. By contrast, the CNS of neonate mammals possesses exceptional parenchymal repair capacity because it contains immature glial cells that have elevated self-renewal and migratory potential. In this talk, Tim O’Shea, PhD, will outline the emerging understanding of how adult astrocytes adaptively reprogram after CNS injury to generate neuroprotective astrocyte borders. He will also provide an overview of various biomaterial and cell grafting strategies that his lab is exploring to enhance the parenchymal repair potential of astrocytes in preclinical models of stroke and spinal cord injury.

 

Speaker:
Timothy O’Shea, PhD 

Assistant Professor Biomedical Engineering Boston University