Houston Methodist

CNR Lecture Series: Using iPSCs and ‘omics to Unravel Mechanisms of Neurodegenerative Disease

Studying inherited age-related neurodegenerative diseases, Dr. Ward focuses on discovering overlapping mechanisms of autosomal-dominant frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). While many of the genes responsible for inherited FTD/ALS are known, little is understood about their mutations or the functional relationships among the genes. A number of FTD/ALS-related genes encode proteins involved in endocytic trafficking and RNA metabolism, suggesting converging disease mechanisms. To identify them, the group employs a combination of unbiased proteomic techniques, cellular and biochemical studies in human iPSC-derived neurons, disease models in mice, and translational studies in human subjects. These studies may ultimately reveal central disease mechanisms of FTD, serving as a foundation for developing disease-modifying therapies.

Michael E. Ward, MD, PhD
Investigator
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Bethesda, MD

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Meeting ID: 917 1244 3000

 

Tuesday, April 20 at 10:00am to 11:30am

Virtual Event
Event Type

Webinar

Attendance Options

Livestream Video

Category

Research

Department & Center
Center for Neuroregeneration, Department of Neurosurgery, Neurological Institute
Speaker

Michael E. Ward, MD, PhD Investigator, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD

Contact Email

sptillett@houstonmethodist.org

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