Houston Methodist

Genomic Subtypes of Hepatocellular Carcinoma Associated with Clinical Outcomes

Hepatocellular carcinoma (HCC) is a heterogeneous lethal disease with large genomic variation. Dr. Lee has identified five clinically and molecularly distinct consensus subtypes, including STM (STeM) with stem cell features, CIN (Chromosome INstable) with high genomic instability and low immune activity, IMH (IMmune High) with high immune activity, BCM (Beta-Catenin with high Male predominance) with β-catenin activation, low miRNA expression, and hypomethylation, and DLP (Differentiated and Low Proliferation) with high HNF4A activity. He and his team also developed and validated a robust predictor of integrated consensus subtype with 100 genes (PICS100).

Presented by:
Ju-Seog Lee, PhD
Professor
Department of Systems Biology, Division of Basic Sciences
UT MD Anderson Cancer Center

Wednesday, April 24 at 3:00pm to 4:00pm

Houston Methodist Research Institute, Ernest H. Cockrell Boardroom R2-311
6670 Bertner Avenue

Event Type

Seminar

Category

Research

Attendance Options

In-Person

Website

http://attend.houstonmethodist.org

Speaker

Ju-Seog Lee, PhD, UT MD Anderson Cancer Center

Contact Email

iamevents@houstonmethodist.org

Subscribe
Google Calendar iCal Outlook