Engineering Strategies to Modulate the Immune System

James Moon, PhD
Chair, Department of Pharmaceutical Sciences
Department of Biomedical Engineering
Department of Chemical Engineering
Biointerfaces Institute
University of Michigan

Dr. Moon develops biomaterial-based strategies to improve cancer immunotherapy by modulating the gut microbiome and activating STING. Oral inulin-gel enhances beneficial microbial communities, strengthens antitumor immunity, and reduces immune-related toxicity, with clinical evaluation underway. He also engineers manganese-containing lipid nanoparticles for safe systemic STING agonist delivery and potent antitumor responses.