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CATEGORIES:Seminar
DESCRIPTION:Weekly lecture series hosted by the Center for Neuroregeneratio
 n and Department of Neurosurgery. \n\n \n\nTuesdays at 9am-10am in Neurosen
 sory Blue Bird Auditorium \n\n \n\nTitle: Nanomedicine and Genome Editing A
 pproaches for Disease Therapies\n\n \n\nAbstract: α-Synuclein exists in an 
 equilibrium between a membrane-bound pool on synaptic vesicles and a cytoso
 lic pool. Aggregated α-synuclein is a major component of Lewy bodies in var
 ious neurodegenerative disorders including Parkinson’s\; however\, it is co
 ntroversial if aggregation of α-synuclein initiates from its lipid-bound or
  unstructured cytosolic state. Strikingly\, all familial Parkinson’s diseas
 e mutations are located within the lipid binding domain of α-synuclein\, wh
 ich suggests that changes in membrane binding affect both α-synuclein physi
 ology and pathology. Using in vitro\, in cellulo and in vivo readouts\, we 
 have identified multiple factors affecting the membrane binding of α-synucl
 ein\, offering new diagnostic and therapeutic strategies for synucleinopath
 ies.
DTEND:20260428T150000Z
DTSTAMP:20260413T111739Z
DTSTART:20260428T140000Z
GEO:29.711295;-95.39894
LOCATION:Neurosensory Building \, Blue Bird Auditorium 
SEQUENCE:0
SUMMARY:Center for Neuroregeneration Visiting Lecture Series - Jacqueline B
 urré\, PhD 
UID:tag:localist.com\,2008:EventInstance_51887707856204
URL:https://attend.houstonmethodist.org/event/Jacqueline-Burre
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