Course Director:  Shane A. Bobart, MD

APOL1-Genes, Environment and Disease

Girish N. Nadkarni, MD, MPH
Irene and Dr. Arthur M. Fishberg Professor of Medicine
Ican School of Medicine, Mount Sinai
System Chief, Division of Data Driven & Digital Medicine
Director, Charles Bronfman Instiute of Personalized Medicine
Mount Sinai Health System

STATEMENT OF NEED

APOL1 genetic variants have been strongly associated with an increased risk of kidney disease, particularly among individuals of African ancestry. However, the mechanisms driving this risk remain incompletely understood. There is a critical need to explore both the biological pathways linking APOL1 to kidney dysfunction and the polygenic and environmental factors that modify disease progression. A deeper understanding of these interactions will inform targeted interventions, improve risk prediction, and guide the development of precision medicine approaches for individuals affected by APOL1-associated kidney disease.

EDUCATIONAL OBJECTIVES

At the conclusion of this activity, the participant should be

• Understand the background of APOL1 and kidney disease.
• Understand the polygenic and environmental contributions
• modifying APOL1-kidney disease.