Houston Methodist Academic Institute

Targeting Adaptive immune system in Alzheimer’s Disease

Inflammation is a significant component of Alzheimer’s disease (AD) pathology. Regulatory T cells (Tregs) play a neuroprotective role by modulating innate and adaptive immune reactions. The Alireza Faridar lab documented that Tregs immunomodulatory function is compromised in AD individuals, shifting the immune system toward pro-inflammatory status. However, dysfunctional Tregs might be a restorable therapeutic target. In a preclinical AD murine model, restoration and expansion of Tregs, modified astrocytes and microglial activities, suppressed neuroinflammation and alleviated AD pathology. This treatment strategy has now been translated into a phase 1/2a clinical trials in AD individuals.

VItually through MS Teams

Monday, December 11 at 10:00am to 11:00am

Virtual Event
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Livestream Video, Recorded Video


Research, Regularly Scheduled Series


Seminar, Alzheimer's Disease, Alireza Faridar

Department & Center
Academic Institute, Office of Curriculum and Educational Development

Alireza Faridar, MD

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