Houston Methodist Academic Institute
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Learning Objectives

  • Describe the pathophysiological mechanisms by which alcohol contributes to the development and progression of fatty liver disease, including its impact on lipid metabolism and inflammation.
  • Explain the role of the intestinal microbiome in the etiology and maintenance of alcohol addiction, including how dysbiosis may influence gut-liver axis interactions and addiction pathways.
  • Identify evidence-based criteria for selecting patients with alcohol use disorder as candidates for liver transplantation, including psychosocial, medical, and ethical considerations.
  • Recognize key risk factors and characteristics associated with relapse in patients who have undergone liver transplantation for alcohol use disorder, such as behavioral patterns, genetic predispositions, and post-transplant support needs.
  • Evaluate the overall impact of alcohol use disorder on liver transplantation outcomes and discuss strategies for multidisciplinary management, including prevention, monitoring, and integration of the program's key topics into clinical practice.
  • Evaluate emerging evidence on the role of GLP-1 agonists in the treatment of alcohol addiction, including their mechanisms of action, potential therapeutic applications, and implications for patients with alcohol use disorder undergoing liver transplantation.
  • Recognize the role of liver transplantation in acute alcoholic hepatitis and the medical/surgical and psychosocial evaluation that is required for optimal outcome and survival.